ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...

DNA methyltransferase 1 (DNMT1) is an important DNA methyltransferase that maintains DNA methylation. The retention of DNMT1 ...

The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Immunotherapy can remove extracellular amyloid plaques from Alzheimer’s brain, but has so far failed to clear intracellular tau tangles. Now, two papers propose a solution: tagging them for ...

已报道的CBApts构建技术面临着一些挑战，包括使用T4连接酶，以及每个核酸适体末端需要13个额外的互补核苷。而新开发的环张力促进的炔烃-叠氮环 ...

Kangpu Biopharmaceuticals, a clinical-stage company based in Hefei, China, announced today that the Company has successfully ...

Scientists at Livzon Pharmaceutical Group Inc., Shanghai Institute of Organic Chemistry and the University of Michigan have identified proteolysis targeting chimeras (PROTACs) comprising an E3 ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

September/2092024/CH-8.jpg" width="1200" height="675" /> CBSE 2024-25 Competency-Based Questions With Answers: Assessment is vital in the learning process as it reinforces the knowledge of the ...

Neurotransmitters are key for synaptic transmission at axon terminals, but their transport modalities remain debated. This ...