Leukemogenesis is proposed to be a multi-step process for normal hematopoietic stem and progenitor cells to be transformed into full-blown leukemic cells, the details of which have not been fully ...

Since the beginning of the 21st century, epigenetics has entered a period of rapid development, especially in the field of biology and medicine. More and more clinical drugs have been found and ...

The goal of the Porter lab is to develop novel therapeutic strategies for leukemia through better understanding of molecular mechanisms of leukemogenesis and treatment resistance. We employ a wide ...

The major focus of the Rau lab is to understand the molecular mechanisms that drive leukemogenesis and therapy resistance with the ultimate goal of translating these findings into better therapies for ...

Many diseases, such as certain cancers, run in families. Often, this is because several related individuals inherit a version of a gene that is faulty and causes the condition. But in a number of ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

Nature. 2010.View in PubMed Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete ...

Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell ...

1 Department of Neurosurgery, The Affiliated Changsha Central Hospital, University of South China, Changsha, Hunan, China 2 Department of Surgery, 94750th Hospital of Chinese People’s Liberation Army, ...

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