Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...

The development of therapeutic drugs is hindered by hepatotoxicity. Early detection of hepatotoxic compounds during the development process allows for better resource allocation toward viable ...

Recent draft guidance highlights the challenges that industry and regulators face to predict rare drug-induced liver injury. At the end of August 2008, the consultation period ended for comments ...

An estimated 15.6 million adults in the U.S. reported use of at least one potentially hepatotoxic botanical supplement within ...

Medically reviewed by Femi Aremu, PharmD Borage is an herb from the Borago officinalis plant, which grows across the Middle ...

Ayurveda supplements often contain multiple herbal ingredients, some of which may be hepatotoxic when taken in inappropriate dosages or durations without professional consultation. While ayurvedic ...

Furthermore, the researchers estimated that 15.6 million U.S. adults have taken at least one herbal supplement in the last 30 days that might be hepatotoxic or damaging to their liver. Healthline ...

ANA, SMA, or anti-LKM1 ≥ 1:80 in adults and ≥ 1:20 in children; no AMA Hypergammaglobulinemia of any degree ANA, SMA or anti-LKM1 ≥ 1:40 in adults; other autoantibodies Interface hepatitis ...

as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; (iii) as promoters of ribosomal RNAsynthesis, stimulating liver regeneration ...

May be antagonized by CYP2C9 inducers (eg, rifampin); adjust dose. Caution with concomitant hepatotoxic drugs (eg, antibiotics, antiepileptics). In a 12-week, randomized, double-blind, dose ...

Fluconazole 2mg/mL; soln for IV infusion. Fluconazole is a highly selective inhibitor of fungal CYP450 dependent enzyme lanosterol 14-α-demethylase. This enzyme functions to convert lanosterol to ...