A key to their investigation was to elucidate the critical involvement of microglia in axonal degeneration post-spinal cord axon injury. Microglia are primary immune cells in the central nervous ...

"Enhanced axonal transport has been linked to neurodegenerative diseases like ALS and Alzheimer's disease," Cisterna and team ...

Studies now suggest that neural protein levels in serum and cerebrospinal fluid reflect axonal damage and predict poor outcome in patients with immune-mediated neuropathy, although validation ...

This important paper takes a novel approach to the problem of automatically reconstructing long-range axonal projections from stacks of images. The key innovation is to separate the identification of ...

However, only motor axons, or axons in charge of muscle movement, are affected. This type of GBS is the same as acute motor axonal neuropathy, except both motor axons and sensory axons (which send ...

Axonal regrowth is a crucial process for forming a compensatory neuronal network after spinal cord injury (SCI), but this is very limited in the adult mammalian central nervous system. BioWorld ...

Iluzanebart, Vigil’s lead clinical candidate, is a fully human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 (TREM2) in people with adult-onset ...

Mapping cell types in MS lesions reveals unique tissue niches and interactions, offering insights into the molecular drivers ...

The investigators added that inflammation and demyelination were reduced, while axonal density oligodendrocytes, ...

After axotomy, severed axons and their synapses engange Wallerian degeneration (WD) to initiate their demise within a day.