This pathway maintains cell survival in the context of autophagy associated with infection and is distinct from autophagic cell death. The potential therapeutic use of modulating this pathway is ...

近日，卢曾军教授课题组在《PLOS PATHOGENS》期刊上发表了题为“Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the ...

Both PINK1 and Parkin might, therefore, be integral components in the autophagic degradation of defective mitochondria. To test this hypothesis, Youle's team conducted standard laboratory tests ...

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key ...

Humans and fruit flies both may become forgetful as they age. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that ...

The research team plans to further explore drug developments that can enhance the autophagic function of astrocytes to prevent or alleviate dementia symptoms, and to conduct preclinical studies in ...

A new resource by Rappe et al (2024) now provides a spatiotemporal landscape of mitophagy changes during mouse brain aging at ...

Because nitrogen fertilizers contribute to global greenhouse gas emissions, scientists are looking for ways to modify ...

1.Watanabe T, Seki T, Fukano T, Sakaue-Sawano A, Karasawa S, Kubota M, Kurokawa H, Inoue K, Akatsuka J, Miyawaki A.: "Genetic visualization of protein interactions ...

Heat shock protein 90 (HSP90) is a molecular chaperone that promotes the proper folding and stability of several oncogenic ...

This useful study examines the function of the rnc gene, which encodes the RNase III ribonuclease, as it relates to virulence of Salmonella Enteritidis. The authors demonstrate that the rnc gene is ...