The starting materials are a benzenediacetaldehyde (a benzene ring with two aldehydes attached), and two equivalents of a phenyl alkyne. The reaction is facilitated by a Lewis acid. Intuitively, one ...

A chemistry article published by researchers at the University of Colorado Boulder was retracted from its journal after an investigation found some of its data was falsified. The article ...

This handbook contains a comprehensive collection of protocols to streamline imaging workflows and ensure reproducible ...

Heath, Sharpless and co-workers synthesized the previously identified bivalent ligand, added a terminal alkyne and repeated the process. The result was a trivalent ligand with a K D of ≈ 50 nM ...

We also focus here on strategies that employ a click reaction, the copper-catalysed azide–alkyne cycloaddition reaction (CuAAC), to allow minimal functionalisation of natural product scaffolds with an ...

Kevin Shea focuses on organic chemistry. His lab uses organic synthesis to investigate new methods for carbon­-carbon bond formation and to develop syntheses of biologically active molecules.

The azide- and alkyne-bearing amino acids react to form a cross-link, constraining the protein structure in a locked conformation. The method could also be used to install probes for imaging and ...

胆红素-牛血清白蛋白偶联物（Bilirubin-Bovine Serum Albumin ...

Methyltetrazine-PEG4-NH-Boc ...