ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I is constitutively active and is responsible for bleb formation in apoptotic cells. Caspases are known to be ...
Molecular mechanisms of mitochondrial energy production and actomyosin contractility were also found to drive the process. Between 6 and 9 hours after triggering initial ovulation, gene expression ...
The group is seeking for a dedicated and enthusiastic post-doctoral fellow. The possible projects include: 1) Understanding the mechanisms by which contractile, mechanosensitive actomyosin bundles ...
Cell adhesion is the process by which cells form contacts with each other or with their substratum through specialized protein complexes. Intercellular adhesion can be mediated by adherens ...
The aim of my research is to gain a stronger understanding of how the cytoskeleton is regulated during cell division, migration and polarity. I am interested in how microtubules and actomyosin control ...
My laboratory studies the regulatory and structural roles of mRNAs in the cytoplasm. Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein ...
Eggs pop out of ovaries. But what propels them has been unknown. Now, researchers from the University of Connecticut explain in an article published in the September 18 issue of the Proceedings of the ...
Using a variety of biochemical, biophysical, and live cell imaging approaches, the Petrie lab aims to understand how intracellular pressure is controlled by actomyosin contractility in migrating cells ...
Conversely patients with elevated levels of VWF have an increased risk of major cardiac events and stroke. We are investigating novel means to regulate VWF secretion that are controlled by an ...