Recognition by TLRs and innate immune recognition in general appear to be directed at conserved products of microbial metabolism 11. The targets of innate immune recognition have at least three ...
Jean-Laurent Casanova and colleagues report in Science a Toll-like receptor 3 (TLR3) deficiency in two children with herpes simplex virus type 1 (HSV1) encephalitis (HSE), and identify autosomal ...
Uptake is a receptor-mediated process resulting in transport into endosomes and activation of TLRs 3, 7 and 8. A small fraction of mRNA escapes from the endosome into the cytoplasm where sensors ...