An inability to detect the regeneration of acetyl-CoA from succinyl-CoA during autotrophic growth of M. sedula led Fuchs and co-workers to propose a modified form of this pathway in this autotroph.

Using these tools we were excited to confirm that the first 'designed' inhibitor, succinyl -L-proline, seemed to be a specific inhibitor of ACE although of very low potency. Subsequent structural ...