Impact of the stem cell niche on aging: we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, ...

This sophisticated and finely tuned network of hematopoietic stem cell maintenance is disrupted during aging, leading to ...

The term 'niche' is borrowed from the description ... Critical barriers to progress in stem cell therapies for the aging brain are: Identification of signals/factors that protect stem cells ...

However, as we age, capacity of stem cells declines, and the resulting drop in tissue repair manifests as the functional decline associated with aging. Our goal is to understand why stem cell activity ...

Scientists from the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging.

The ability of the bone marrow to produce healthy blood cells declines significantly with age, leading to age-related ...

However, beyond these conventional approaches, a pioneering treatment has offered an alternative solution to address the multifaceted concerns of aging: stem cell treatments. From the name itself ...

Our study provides compelling evidence that when a small subset of blood stem cells overproduces innate immune cells, this drives the aging of the immune system, contributes to disease ...

In healthy rodent brains, newborn neurons are constantly generated in the stem cell niche, known as the subventricular zone (SVZ). These cells might help to repair a brain that has been damaged by ...

New formation of neurons from stem cell niche disrupted after stroke Date: October 24, 2024 Source: University of Freiburg Summary: Researchers studied what happens immediately after a stroke in ...