信号传导所需的蛋白聚糖（proteoglycan）的形成。这种信号传导对细胞分化和原始条纹（primitive streak）延伸至关重要。这种结构最终形成神经板 ...

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite ...

We have speculated that HSV1 and apoEs might compete for entry into neuronal cells through heparan sulphate proteoglycan molecules (the initial site of attachment for entry for each), with apoE4 ...

Two of the novel regions are close to genes that immediately suggest clinical implications for osteoarthritis. One, CHST11, affects cartilage proteoglycan (proteins in the cartilage modified with ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

The aim of this work was to investigate whether in patellar tendinopathy there is a change in the gene expression of the matrix proteinases involved in proteoglycan catabolism including the MMPs and ...

Dr. Jill Richter is an Associate Professor with Tenure of Surgery in the Division of Trauma & Acute Care Surgery at UAB. Dr. Richter is a biomedical engineer by training, and she received her B.S. and ...

The study found that many genes that provided resistance to the cytotoxicity of the spitting cobra venom were involved in proteoglycan biosynthesis and that heparinoids could potentially inhibit ...