The major core protein families include the glycosylphosphatidylinositol (GPI)-linked glypican, the transmembrane protein syndecan and the secreted perlecan. During their biosynthesis, GAG chains ...
The opportunity to author peer-reviewed publications is crucial for graduate students pursuing an advanced degree in biological sciences. This experience is invaluable as it mirrors the professional ...
Our research focuses on adhesion between myelinating cells, axons and the extracellular matrix and the signals that promote myelination. One of our major efforts has been the study of laminin ...
1 2 In the basement membrane perlecan is the major component that bears heparan sulphate. Rheumatoid arthritis (RA) is characterised by chronic inflammation of the synovium of the joints, resulting in ...
Heparan sulphate proteoglycans can be categorised into two main families: those of the extracellular matrix, including perlecan, agrin, and collagen XVIII; and those of the cell surface, such as the ...
The term ‘therapeutic angiogenesis’ originated almost two decades ago, following evidence that factors that promote blood vessel formation could be delivered to ischaemic tissues and restore blood ...
Basement membranes (BMs) are complex macromolecular networks underlying all continuous layers of cells. Essential components include collagen IV and laminins, which are affected by human genetic ...
Synaptic positions underlie precise circuit connectivity. Synaptic positions can be established during embryogenesis and sustained during growth. The mechanisms that sustain synaptic specificity ...
a Division of Respiratory Medicine, Thoracic Clinics, Karolinska Hospital, SE-171 76 Stockholm, Sweden, b University Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK Dr B ...
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