Duration of effect and time to rescue medication were also recorded. Results: The pharmacokinetics of intravenous fentanyl reflected a 2-compartment model with a clearance of approximately 1.5 L/min.

Pharmaceutical spectroscopy techniques like NMR, mass spectrometry, and UV-Vis play essential roles in pharmacokinetics, supporting each stage of drug development from discovery and preclinical ...

Following oral administration of a drug, extent and speed of absorption is influenced by several processes. With respect to the formulation of the drug, this comprises: release of the active ...

导读Introduction近年来，我国终末期肾病（ESRD）发病率逐年增长并且增幅加快，每年约有2%的患者进入ESRD[1]。肾脏替代治疗是治疗肾功能衰竭的主要方式，我国最新透析数据显示，截止2023年底，中国大陆地区透析登记患者总人数已经超过10 ...

复方磺胺甲唑是由甲氧苄啶（trimethoprim，TMP）和磺胺甲唑（sulfamethoxazole，SMZ）以固定剂量（1∶5）组成的复方制剂。TMP-SMZ属于上个世纪50年代研发的抗菌药物，仍广泛用于特定感染性疾病的预防与治疗，作用机制涉及 ...

On July 31, 2024, Adial announced that, after an extensive review of data and information from the Onward Study, it had filed a new patent application to protect core assets and extend IP exclusivity ...

Background: There is strong experimental evidence of a neuroprotective effect of melatonin in immature animals. However, pharmacokinetic (PK) data on melatonin in preterm infants is lacking.

The topline data showed ISM001-055 to have improved the forced vital capacity (FVC) of IPF patients studied 12 weeks after ...

Topline results are anticipated in the first half of 2026. The Phase 2b LUMUS program for ESK-001 in SLE is designed to evaluate the efficacy, safety and pharmacokinetics of multiple doses of ESK-001 ...