为了揭示RPL22发挥作用的分子机制，研究人员首先通过SUnSET实验发现敲除RPL22的人间充质祖细胞的整体翻译水平并没有发生明显变化；随后通过构建缺失核糖体功能的RPL22突变体，发现其仍可以显著促进人间充质祖细胞的衰老，提示RPL22的促衰老能 ...

研究人员发现，很多短非编码RNAs此前并未进行过测序，而且其中很多RNAs都能激活宿主机体的免疫系统，这些研究发现不仅揭示了小非编码RNAs如何驱动免疫系统对诸如结核病等感染产生反应，而且还能为评估机体免疫反应的严重程度提供潜在的治疗性靶点和生物标志 ...

This is the 8th in a popular conference series going back to 1981 that brings together nucleic acids scientists across a broad area but with particular emphasis on chemistry, biochemistry and ...

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蛋白质乙酰化 作为一种重要的蛋白质翻译后修饰参与多种生理过程，因此在植物生长发育及环境适应中发挥着重要调控作用。蛋白质乙酰化修饰机制和生物学功能的解析可为作物育种及改良提供新的思路和方法。

硫嘌呤类药物广泛用于治疗白血病、风湿性疾病、皮肤病、炎症性肠病以及实体器官移植排斥反应。经典认为该类药物主要通过抑制嘌呤核苷酸、DNA及RNA的合成发挥抗增殖作用。然而该经典药理学机制并不能完全解释其体内活性。

The Purdue University Institutional Biosafety Committee (IBC) reviews research protocols involving the use of recombinant DNA (rDNA), synthetic nucleic acids, and/or biohazardous agents that present a ...

A researcher in Purdue University’s College of Science is developing a patent-pending platform technology that mimics the ...

In response to this gap, leaders in the nucleic acid synthesis industry took a step towards self-regulation. In 2009, they formed the International Gene Synthesis Consortium (IGSC) and established a ...

NanoVation Therapeutics partners with Novo Nordisk to develop genetic medicines for cardiometabolic and rare diseases, ...