So far, the best-characterized function of VHL has been as a component of an E3 ubiquitin ligase complex, which mediates degradation of the hypoxia-inducible factor (HIF) under normoxic conditions.

Koay EJ and Athanasiou KA (2008) Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality. Osteoarthritis Cartilage ...

However, a team of researchers from Kazuhiko Ogawa’s laboratory led by Osaka University was the first in the world to demonstrate that cell survival rates increase even under normoxic conditions ...

gmail.com Well-trained academy rugby league and rugby union academy players were randomised to complete 4 weeks of hypoxic or normoxic repeated sprint training during the preseason period.

A research group led by Osaka University has demonstrated for the first time in the world that a newly-developed accelerator ...

For select sporting activities, time trials or other direct performance measures could be completed using a normoxic and a hypoxic inspirate. It is to be remembered that most hypoxic delivery models ...

However, a team of researchers from Kazuhiko Ogawa's laboratory led by Osaka University is the first in the world to demonstrate that cell survival rates increase even under normoxic conditions ...

The core provides expertise in molecular energetics and metabolomics techniques in a variety of species from yeast to mice. The Mitometabolism Core houses two Seahorse XF24 machines for normoxic as ...

During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent chemoradiotherapy has improved cancer care dramatically. Significant contributions have been made by ...

Summary and Introduction Clinical Application—Disease Entities Theoretical Framework for Therapy−The 'Steel Paradigm' Conclusion References Theoretical Framework for Therapy−The 'Steel ...

Recent findings unveiled a completely new role for β-catenin during colorectal tumorigenesis mediating adaptation to hypoxia, as summarised below. Under normoxic conditions, COX-2 expression can be ...