It chooses two amino acids nearby in linear sequence, so only one mutagenic primer is needed. This simultaneous mutagenesis method increased the enantioselectivity of an epoxide hydrolase from 4.6 ...
He often said that he thought there was too much focus on substances that were technically mutagenic but that were no more likely to cause DNA damage than the “natural” chemicals found in frui ...
In lab experiments, these chemicals have been found to be mutagenic — that is, they cause changes in DNA that may increase the risk of cancer. This being said, measuring the actual level of risk ...
This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide solid evidence to connect proteostasis with gene ...
Fundamental biomolecular interaction mechanism analysis Kinetic and equilibrium binding Mutagenic studies, binding site and epitope specificity maps Vaccine efficacy tracking Compound, or antibody, ...
In addition, we study an ancient yet error-prone DNA repair pathway, termed micro-homology mediated end-joining, and focus on polymerase theta, a key enzyme underlying mutagenic repair. Lastly, we ...