数千年来，从希腊哲学家希波克拉底和柏拉图开始，禁食被认为有益健康。间 歇性禁食 和 生酮饮食 有多种益处，如减重、抗炎、增强脑功能和抗癌。 禁食和生酮饮食通过将能量来源从葡萄糖转变为酮体，激活多条细胞信号通路 。

禁食与多种健康益处相关。禁食、低碳水化合物高脂肪饮食或运动等方式诱导的生酮作用，已被证实能激活多种细胞信号通路。然而，尽管经过了数十年的研究，禁食信号如何诱导蛋白质组水平的基因表达变化，从而建立起酮体产生的代谢程序，这一问题仍未得到充分阐明。

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AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress ... 2010.View in PubMed Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ. mTOR ...

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