For example, researchers have found mutations of the MTHFR gene, or methylenetetrahydrofolate reductase, to be linked to conditions like depression, bipolar disorder, certain cancers, and high ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

当叶酸经过肠道中，一个名为亚甲基四氢叶酸还原酶（MTHFR）的酶起着关键作用，它负责将叶酸最终转化为5-甲基四氢叶酸（活性叶酸），这是一种更 ...

Polymorphisms in genes encoding proteins in two major cellular pathways influenced by MTX, namely the folate and adenosine pathways, and their association with response to MTX have been examined ...

Background: Methotrexate (MTX) is the first-line treatment option for newly diagnosed rheumatoid arthritis (RA) patients. However, 50–70% of the patients respond to treatment and 30% suffer ...

A former DART program trainee, Khass earned his Master’s degree in Biochemistry where he focused on identifying polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) in mothers of ...

It illustrates balanced polymorphism because carriers are resistant to malaria, an infection by the parasite Plasmodium falciparum that causes cycles of chills and fever. The parasite spends the ...

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Individuals with MTHFR gene mutations often depend on Methylfolate supplements. These genetic changes can lead to a lack of folate, an essential nutrient that plays a crucial role in various body ...