No patients with nontoxic multinodular goiter (n = 34), toxic nodular goiter (n = 23), or toxic diffuse goiter, either untreated (n = 49) or euthyroid while taking methimazole (n = 33), had ...
However, they are not completely safe to use during pregnancy as methimazole increases risk of neonatal malformations and propylthiouracil increases risk of maternal hepatotoxicity ...
In mild disease this can be done over a period of weeks with the administration of a thionamide drug (methimazole or propylthiouracil). An alternative is administration of radioactive iodine ...