Idiopathic pulmonary fibrosis is a chronic, progressive, incurable lung disease, leading to irreversible lung tissue ...

Aileron Therapeutics' Phase 1b trial shows LTI-03 improved biomarkers and reduced SPD levels, indicating the potential to ...

BPD is now considered as resulting from the impact of injury, including oxygen toxicity, barotrauma/volutrauma, and infection, on a very immature lung, which leads in turn to arrest of normal ...

These cells, in turn, express a receptor on their surface that promotes interactions with fibroblast cells on the outside of the lungs, leading to excess collagen production that can spur lung ...

Waltham, Massachusetts Friday, November 15, 2024, 15:00 Hrs [IST] ...

and lung diseases. Yet fibrosis of these organs remains a deadly disease with limited treatments. "The crosstalk between the immune system and fibroblasts is even more complex than we expected ...

Project Leader: Victor Thannickal, M.D. Idiopathic pulmonary fibrosis (IPF) is chronic, progressive lung disorder with high mortality, and limited therapeutic options. Studies performed during Cycle I ...

High-dose LTI-03 (5 mg BID), a Caveolin-1 related peptide, reduced expression of multiple profibrotic proteins in both ...