Previous studies have shown that IL-15 is critical to the induction of T-cell large granular lymphocyte (T-LGL) leukemia. A Phase I trial of a humanized antibody (Hu-Mikβ1) to the IL2/IL15Rβ ...

Nine T-LGL leukemia patients were included in this trial. The diagnosis of T-LGL leukemia was established by histology and flow cytometry (for C3 + CD8 + CD4 − CD57 + T-LGL cell count >1000/µl ...