In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...

While responses to inflammation may be necessary to maintain normal and emergency hematopoiesis, it may be deleterious ... syndromes and will likely provide novel targets for drug development.

A recent study in zebrafish presents a potentially important new system for studying the process of stem cell biology and hematopoiesis, the process by which blood is produced. The zebrafish has ...

Progress in biomedical research toward the development of efficient new therapeutics requires the study of human physiology and pathology in vivo. However, rigorous human disease experimentation ...