Evidence presented supports a strong positive correlation between ERBB-2 overexpression and cyclooxygenase upregulation in human cholangiocarcinogenesis. Combination drug targeting of ERBB-2 and ...
In 1994, P. Miller and colleagues looked at what would happen to cellular ERBB2 levels when cells were treated with herbimycin A (Miller et al. 1994). They used cells that normally express ERBB2 ...
Each ERBB receptor has distinct locations and numbers of tyrosine phosphorylation sites on its C-terminal tails; there are twelve on ERBB1, six on ERBB2, and eleven on ERBB3 (Jones et al.
Aims: To determine the maximum tolerated dose (MTD), safety and anti-tumor activity of afatinib combined with docetaxel in advanced cancer. Patients & methods: The MTD was determined from dose ...
早期的癌症是比较容易治的,乳腺癌是女性易患的癌症中比较常见的一种。我们需要了解乳腺癌的早期症状,要早发现早治疗。平时多注意这方面的问题,如果发现有异常就要及时到医院检查,以免去晚了耽误了治疗的最佳时期。 12种人最容易患乳腺癌 ...
*仅供医学专业人士阅读参考就在本月初,国家药品监督管理局(NMPA)正式批准德曲妥珠单抗(T-DXd),用于治疗存在HER2突变且既往接受过至少一种系统治疗的不可切除的局部晚期或转移性非小细胞肺癌(NSCLC)成人患者,成为我国首个且唯一批准的HER ...
*仅供医学专业人士阅读参考ctDNA监测有望为晚期ER+乳腺癌治疗耐药后进展提供早期预警。过去十年中,晚期雌激素受体阳性(ER+)乳腺癌取得了重大进展[1]。内分泌治疗及细胞周期蛋白依赖性激酶4/6抑制剂(CDK4/6i)的发展和应用显著延长了患者无 ...
WALTHAM, Mass. and BOULDER, Colo., Nov. 12, 2024 (GLOBE NEWSWIRE) -- Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined ...
【导读】胃肠道间质瘤(GIST)在临床上具有异质性,在个体患者中表现出不同程度的疾病侵袭性。团队全面描述了117例GIST队列的基因组和转录组学景观,包括来自105例患者的31例低风险、18例中危、29例高风险、34例转移性和5例新辅助GIST。20 ...
10月14日,据阿斯利康中国宣布,由阿斯利康和第一三共联合开发、商业化的优赫得(英文商品名:Enhertu,通用名:注射用德曲妥珠单抗)已于10月9日获得中国国家药品监督管理局附条件批准,用于治疗存在HER2(ERBB2)激活突变且既往接受过至少一种系统治疗的不可切除的局部晚期或转移性非小细胞肺癌(NSCLC)成人患者。 这已是德曲妥珠单抗在华获批上市两年内拿下的第四个重磅新适应证,拓展了继乳腺癌 ...