Bile acids are byproducts of cholesterol metabolism in the liver and constitute the primary components of bile. Disruption of ...

This study examined the natural history of infants born with alpha-1 antitrypsin (AAT) deficiency and liver disease ... by too few bile ducts resulting in cholestasis, can damage not only the ...

FIC1 disease collectively refers to a group of autosomal-recessive familial liver disorders characterized by intrahepatic cholestasis due to mutations in the ATP8B1 gene (initially named FIC1).

Ursodeoxycholic acid (UDCA) is widely used for the treatment of chronic cholestatic liver diseases. However, a recent randomized, controlled trial has surprisingly shown that the use of high-dose ...

Cholestasis presents a complex challenge in liver disease, with mitochondrial dysfunction playing a central role in its pathogenesis. This review underscores the importance of targeting ...

Sokol M.D. When first encountering an infant or child with cholestatic liver disease, it is essential that diagnostic evaluation be conducted promptly in order to (i) recognize disorders amenable ...

European Commission grants conditional marketing authorization for Iqirvo® (elafibranor), first-in-class new treatment for primary biliary ...

Drug-induced liver injury including cholestasis is another form of acquired liver disease, accounting for approximately 2 to 5% of hospitalizations for jaundice, 10% of cases of hepatitis in all ...

Thus, within the past 5–10 years, it has become possible to tease apart not only the means by which the liver is damaged by rare single-gene defects in critical hepatobiliary genes, but also how these ...

European Commission grants conditional marketing authorization for Iqirvo® (elafibranor), first-in-class new treatment for primary biliary cholangitis (PBC), a rare liver diseaseApproval follows posit ...