Notably, the study found that reducing CD39 expression through shRNA knockdown impaired the cytotoxicity and proliferation of ...

The findings from this study offer valuable insights into the role of CD39 in CAR-T cell therapy for HCC. By demonstrating that moderate CD39 expression is associated with optimal CAR-T cell ...

In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a recent study has identified a pivotal role for CD39 expression in ...

The researchers further explored the synergistic potential of combining mdivi-1 with CD39 knockdown in CAR-T cells, demonstrating that this approach could significantly boost the antitumor ...