Several types of human cancer, particularly colon cancer ... the authors identified a number of residues in the Frizzled 8 CRD that, when mutated, disrupt Wnt binding (shown in red for one ...

2006;3(5):267-274. The WNT signaling pathway. (A) In the absence of WNT binding to frizzled, dishevelled remains unactivated and β-catenin is targeted for degradation via the adenomatous ...