Cleavage of the linker releases and activates the drug payload, an optimized camptothecin with a clinically validated mode of action. Animal studies show that this two-step targeting to-, and ...

Lilly is paying $13 million upfront for exclusive rights to use ImmunoGen's novel camptothecin molecules in ADCs against drug a first batch of drug targets, with an option on a second batch that ...

1b,d), and even some traditional plant natural products such as podophyllotoxin and camptothecin, both of which became the basis for successful anticancer compounds, are now thought to be produced ...

Continued enrollment and dose escalation in Phase 1 study of VIP943, a potentially best-in-class anti-CD123 antibody-drug conjugate (ADC); additional data expected by early 2025 Completed Phase 1 dose ...

Continued enrollment and dose escalation in Phase 1 study of VIP943, a potentially best-in-class anti-CD123 antibody-drug conjugate (ADC); additional data expected by early 2025 Completed Phase ...

News, July 26, 2020 New FDA Orphan Drugs The FDA has granted orphan drug designation for 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin for the treatment of osteosarcoma, 5,7-dihydroxy-3-(4 ...

While uncertainty often casts a shadow on the Street, U.S. investors welcomed the presidential and congressional election results with a late-night surge that carried into this morning. The Dow Jones ...

Last year, it also revived a collaboration with ImmunoGen, more than a decade after backing away from a relationship, to claim an interest in its camptothecin payload technology. That deal ...

Good afternoon. We will begin the MacroGenics 2024 third-quarter corporate progress and financial results conference call in ...