Cleavage of the linker releases and activates the drug payload, an optimized camptothecin with a clinically validated mode of action. Animal studies show that this two-step targeting to-, and ...

Lilly is paying $13 million upfront for exclusive rights to use ImmunoGen's novel camptothecin molecules in ADCs against drug a first batch of drug targets, with an option on a second batch that ...

1b,d), and even some traditional plant natural products such as podophyllotoxin and camptothecin, both of which became the basis for successful anticancer compounds, are now thought to be produced ...

Current anticancer drugs like Camptothecin, Topotecan, and Irinotecan target Top1, but cancer cells often develop resistance ...

While uncertainty often casts a shadow on the Street, U.S. investors welcomed the presidential and congressional election results with a late-night surge that carried into this morning. The Dow Jones ...

This valuable paper shows image correlation spectroscopy (ICS) as a new tool to analyze the clustering of proteins involved in DNA damage response (DDR). The solid evidence presented demonstrates that ...

News, July 26, 2020 New FDA Orphan Drugs The FDA has granted orphan drug designation for 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin for the treatment of osteosarcoma, 5,7-dihydroxy-3-(4 ...

Last year, it also revived a collaboration with ImmunoGen, more than a decade after backing away from a relationship, to claim an interest in its camptothecin payload technology. That deal ...

MacroGenics (NASDAQ: MGNX) Q3 2024 Earnings Call Nov 05, 2024, 4:30 p.m. ET ...