Tumor cells were classified into three metabolic states: OXPHOS+, OXPHOS-, and PPP+, with PPP+ cells showing increased ...

We found that splice isoform switching of the CD44 gene must take place in order for cells to undergo EMT. We also discovered a novel splicing-mediated pathway that drives cancer metastasis. We ...

本报讯（德阳传媒记者曾征）近日，第十一届中国青年创青春大赛（数字经济专项）在江西省共青城市举办。

▎药明康德内容团队编辑 在肿瘤的各类细胞类型中，肿瘤起始细胞是一类独特的细胞群，它们不仅具有增强的干性和自我恢复能力，还具有很强的致癌潜力，可以驱动肿瘤发生、维持和复发。同时肿瘤起始细胞具有高度可塑性，可以从没有此类特性的肿瘤细胞转化而来。过往研究表 ...

We found that pro-inflammatory M1 macrophages secreted factors that increased the expression of stem cell markers such as ...

在肝癌领域，常用细胞表面蛋白如CD24、CD44、CD90、CD133和EPCAM等来识别潜在的肿瘤起始细胞。面对众多潜在的候选分子，如何区分和确定这些标记分子在肝癌精准治疗中的作用和重要性成为一个 ...

What is Known About the Estrogen Deficiency of Menopause & Specific Autoimmune Diseases It is known that many natural, pathological and therapeutic conditions can change serum estrogen levels ...

编辑丨王多鱼排版丨水成文肿瘤起始细胞（TIC）是一群具有自我更新能力并能够驱动肿瘤发生、维持和复发的细胞亚群。它们在肿瘤异质性、侵袭性和耐药性方面发挥关键作用。在肝癌中，通常使用细胞表面蛋白，如CD24、CD44、CD90、CD133和EPCAM等， ...

肿瘤异质性对理解驱动肿瘤进展和转移的机制提出了巨大的挑战，肝细胞癌(HCC)在细胞水平上的异质性尚不清楚。复旦大学黄傲/周俭团队最新发表在《Molecular Cancer》上的一项突破性研究，标题为“Single-cell tumor ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...