Researchers from the Josep Carreras Leukaemia Research Institute have found that the efficacy of varni-cel, a CAR-T infusion ...

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity.

The stem-like CD4 T cells have the ability to renew themselves and transform into different immune cell types. These cells are marked by two specific proteins, PD1 and TCF1, which help determine ...

The vaccine boosted the power of cancer-fighting immune cells, but only if the tumors were in an early stage and not advanced state. The vaccine was previously tested in human clinical trials for ...

“The impaired numbers of CD3 + T cell may contribute to a weakened anti-tumor response, potentially leading to a poorer prognosis ... The number of IgG, B-lymphocytes, CD4/CD8, CD4 + T-lymphocytes, ...

which studies how T cells interact in cancer, autoimmunity, and infection, discovered a role for CD4 T cells in helping to overcome CD8 T-cell dysfunction that has opened a door to new targeted ...

It can restart a powerful anti-tumor immune response and enhance responsiveness to PD1 blockade in animal models." The findings suggest that almost all patients have this stem-like CD4 T cell in ...

Memory CD8 + T cells are the mature version that has encountered an antigen before and create an immune response if it is reencountered. Lower levels of apoptosis were also seen in the CD4 + T ...

Both published and newer data suggests that DNase I impedes neutrophil tumor infiltration, promotes CD4 and CD8 T cell infiltration, and enhances intratumoral T cell activation. DNase I plus -CTLA-4 ...