Artificial biosynthetic pathways are typically assembled and optimized progressively, from earlier to later steps. This commentary highlights the potential of an alternate regressive method for ...

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The biosynthetic pathway of specific steroidal compounds in nightshade plants (such as potatoes, tomatoes and eggplants) starts with cholesterol. Several studies have investigated the enzymes involved ...

这项研究首次证明，晚年限制叶酸摄入量可能更有利于代谢健康和长寿。通过减少细胞生长和合成代谢，增强代谢可塑性，叶酸限制有助于健康衰老。未来的研究将进一步探索这种现象背后的机制，并开发安全有效的治疗干预措施，以促进健康老龄化。

There had to be other missing links to consider. What have scientists overlooked? My recently published research suggests ...

Pharmaceutical scientists from the National University of Singapore (NUS) have identified and characterized a unique ...

1.AmagaiK., Ikeda H., Hashimoto J., Kozone I., Izumikawa M., Kudo F., Eguchi T., Nakamura T., Osada H., Takahashi S., and Kazuo Shin-ya K.: "Identification of gene ...

We also wanted to find out whether we could reconstitute the biosynthetic pathway after identifying the missing component. An important aspect of our study was also to find out more about the ...

Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function ...

The absence of SREBP in the Sre1 mutant thus caused C. neoformans to become hypersensitive to nickel. Several sterol ...

This study provides convincing evidence for functional subpopulations of β-cells responsible for Ca2+ signal initiation and maintenance using novel three-dimensional light sheet microscopy imaging and ...