*仅供医学专业人士阅读参考APOE4是阿尔茨海默病（AD）的最强遗传风险因素，降低AD发病年龄，促进AD的典型病理，包括β-淀粉样蛋白（Aβ）和过度磷酸化的tau蛋白（p-tau）沉积。APOE4在AD发病机制中的作用十分复杂，仍没有被完全揭示。星形 ...

这些揭示黑色素瘤细胞保护自身免于铁死亡的新见解或能帮助确定ApoE基因或能作为黑色素瘤中的关键抗铁死亡的因素，由于ApoE是晚发性 阿尔兹海默 病的最大遗传风险因素，因此，这项对黑色素瘤进行的研究揭示了ApoE生物学的复杂性，并有望为研究人员提供希望 ...

引言阿尔茨海默症（Alzheimer’s disease, AD）的临床前期（preclinical ...

Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s ...

Scientists monitor mpox virus mutations and human-to-human transmission, impacting vaccination strategies in Africa.

The link between lipid metabolism and glaucoma pathophysiology could guide future research and treatment strategies.

Patrizia Agostinis (VIB-KU Leuven) has found that melanoma cell populations protect themselves from a form of cell death called ferroptosis by secreting the lipoprotein apolipoprotein E (ApoE).

One of the key advantages of apolipoprotein testing lies in its ability to provide a more accurate assessment of cardiovascular risk compared to conventional lipid panels. For individuals with ...

A small tweak in the dosing regimen of Eli Lilly’s Alzheimer’s disease drug Kisunla has reduced brain swelling of patients in ...

Drs Pavan Brahmbhatt and Amit Agarwal discuss best practices for managing amyloid-related imaging abnormalities in patients ...