One of the first antiangiogenesis compounds to be proposed and evaluated for treatment of patients with cancer was endostatin, a 20-KD proteolytic fragment of collagen XVIII, which inhibits ...

§ p = 0.0001 between temsirolimus and IFN-α. ¶ p = 0.0001. # p = 0.0001. ** p = 0.001. NR: Not reported; ORR: Overall response rate; OS: Overall survival; PFS ...

Later on, Judah Folkman's hypothesis that antiangiogenesis could be a strategy to treat cancer and possibly other disorders 5 generated a great deal of enthusiasm and gave a major boost to the field.

The expression of IL-12 helps immune cells to infiltrate and attack tumors, while short hairpin RNA targeted against vascular endothelial growth factor (shVEGF) induces strong antiangiogenesis.

Let me explain what I mean by that. Judah Folkman is the champion of angiogenesis and antiangiogenesis in the world. His first new drug was this drug called Endostatin and it was supposed to ...