The excessive cosolute densities in the intracellular fluid create a physicochemical condition called macromolecular crowding (MMC). Intracellular MMC entropically maintains the biochemical ...

The group is seeking for a dedicated and enthusiastic post-doctoral fellow. The possible projects include: 1) Understanding the mechanisms by which contractile, mechanosensitive actomyosin bundles ...

Cytokinesis is a key event in the cell cycle requiring tight coordination of mitotic spindle assembly, actomyosin contractility and membrane dynamics, but the mechanisms that regulate cytokinesis are ...

Chen, X., Fansler, M.M., Janjoš, U., Ule, J., and Mayr, C. (2024). The FXR1 network acts as signaling scaffold for actomyosin remodeling. Cell, in press. Also on ...

The aim of my research is to gain a stronger understanding of how the cytoskeleton is regulated during cell division, migration and polarity. I am interested in how microtubules and actomyosin control ...

My laboratory studies the regulatory and structural roles of mRNAs in the cytoplasm. Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein ...

Using a variety of biochemical, biophysical, and live cell imaging approaches, the Petrie lab aims to understand how intracellular pressure is controlled by actomyosin contractility in migrating cells ...

Then, an enzyme called actomyosin starts to break down the muscle fibers in a cut and the meat becomes far more tender. That tenderness will increase the longer the product is left to sit on a rack, ...

Conversely patients with elevated levels of VWF have an increased risk of major cardiac events and stroke. We are investigating novel means to regulate VWF secretion that are controlled by an ...