Controlling Superselectivity of Multivalent Interactions with …
网页We found that multivalent probes retained their superselective binding behavior at fluid interfaces. Supported by numerical simulations, we demonstrated that, as a consequence of receptor clustering, superselective binding was enhanced and shifted to lower receptor densities at fluid interfaces.
Determinants of Superselectivity─Practical Concepts for …
网页2023年3月14日 · Superselectivity refers to the sharp discrimination of surfaces (e.g., on cells or cell compartments) by their comparative surface densities of a given receptor. This feature is different from the conventional “type” selectivity, which discriminates surfaces by their distinct receptor types.
SuperSelective primer pairs for sensitive detection of rare …
网页2021年11月17日 · The use of SuperSelective primer pairs should enhance the sensitivity of multiplex PCR assays that identify and quantitate somatic mutations in liquid biopsies obtained from patients with cancer,...
Superselective Targeting Using Multivalent Polymers
网页2014年1月9日 · Using this experimental platform in combination with a simple analytical model, we demonstrate that multivalent polymers discriminate sharply between surfaces displaying low and high densities of binding sites, thus allowing for superselective targeting.
Design Principles for Super Selectivity using Multivalent Interactions
网页2017年12月15日 · This chapter introduces a simple analytical model to predict the overall strength of interactions based on physicochemical characteristics of multivalent binders. Super-selective behaviour can be exhibited by multivalent systems that can increase the number of possible bonds as the density of receptors increases.
Phys. Rev. Lett. 132, 118202 (2024) - Designing Superselectivity in ...
网页2024年3月12日 · When the bridges are excessive, the system becomes insensitive to bridging strength due to entropy-induced self-saturation and shows a superselective desorption with respect to the linker density. Counterintuitively, lower linker density or stronger bridging strength enhances the superselectivity.
Spatiotemporal control and superselectivity in supramolecular …
网页2013年7月8日 · This phenomenon is reversible and affords spatiotemporal control over the monomer distribution inside the supramolecular polymer by superselective binding of single-strand DNA to positively charged receptors.
Design principles for super selectivity using multivalent interactions
网页2016年8月3日 · In this chapter we focus on super-selectivity: the high sensitivity of the strength of multivalent binding to the number of accessible binding sites on the target surface. For example, the docking of a multivalent particle on a cell-surface can be very sensitive (super-selective) to the concentration of the receptors to which the multiple ...
用于检测和定量液体活检中罕见体细胞突变的多重超选择性 PCR 检测
网页2023年12月21日 · 用于检测和定量液体活检中罕见体细胞突变的多重超选择性 PCR 检测. SuperSelective 引物凭借其独特的设计，能够在常规多重 PCR 分析中同时鉴定和定量遗传参考基因和罕见的体细胞突变，同时几乎消除与目标突变密切相关的大量野生型序列的信号。. 这些检测灵敏 ...
Superselective targeting using multivalent polymers - PubMed
网页2014年2月5日 · Based on predictions from a simple analytical model, we propose that this superselective behavior arises from a combination of enthalpic and entropic effects upon binding of nanoobjects to surfaces, accentuated by …