Recent Advances in Synthetic Methods for Radioiodination
网页2020年5月5日 · Radioiodinated compounds are widely used for a range of applications across various fields of medicinal and biological sciences. In combination with PET and SPECT technologies, these compounds are now well established for the noninvasive in vivo visualization and diagnosis of disease.
Design of Radioiodinated Pharmaceuticals: Structural Features Affecting ...
网页2017年4月26日 · Radioiodinated pharmaceuticals are convenient tracers for clinical and research investigations because of the relatively long half-lives of radioactive iodine isotopes (i.e., 123 I, 124 I, and 131 I) and the ease of their chemical insertion. Their application in radionuclide imaging and therapy may, however, be hampered by poor in vivo ...
Radioiodination Chemistry and Radioiodinated Compounds
网页An overview of the chemistry of radioiodination is presented. The focus is directed on the labeling of iodine-containing radiopharmaceuticals, with emphasis on practical aspects of the various radioiodination methods. The advantages and disadvantages of these methods...
Synthesis of Radioiodinated Compounds. Classical Approaches …
网页2022年11月9日 · This review demonstrates the progress in the synthesis of radioiodinated compounds over the past decade. The possibilities and limitations of radiopharmaceuticals with different iodine isotopes, as well as the synthesis of low and high molecular weight compounds containing radioiodine, are discussed.
Radioiodination - an overview | ScienceDirect Topics
网页Radioiodination is a common way to label proteins A or G or secondary antibodies (methods 1 and 2 in Fig. 23.4). A suitable isotope is 125 I, which is easily detected by autoradiography and has a relatively long half-life (60 days); further, its low energy minimizes radiation hazards.
Biomedical applications of radioiodinated peptides
网页2019年10月1日 · This review outlines the synthetic efforts in the preparation of radioiodinated peptides highlighting the importance of radioiodine in nuclear medicine, giving an overview of the most relevant radioiodination strategies that have been employed and describes relevant examples of their use in the biomedical field.
Radioiodination of BODIPY and its application to a nuclear and …
网页2017年6月14日 · In this study, for the first time, we revealed that radioiodinated BODIPY can function as a new agent useful for the nuclear and optical dual functional labeling of various biologically active...
Radioiodinated 4-(p-Iodophenyl) Butanoic Acid-Modified …
网页2021年10月6日 · Overexpression of estrogen receptors (ERs) is one of the important characteristics of most breast cancers. We aim to develop a new type of ER-specific radioiodine-labeled estrogen derivative ( [ 131 I]IPBA-EE), which was modified with an albumin-specific ligand 4- ( p -iodophenyl) butyric acid …
Recent Advances in Synthetic Methods for Radioiodination
网页2020年7月2日 · Early reported synthetic methods for the incorporation of radioiodine have generally involved high temperature reactions or strongly oxidizing conditions. To overcome these limitations and to cope with the demand for novel radioiodinated probes, there has been a surge in the development of new synthetic methodology for radioiodination.
Synthesis of Radioiodinated Compounds. Classical Approaches …
网页2022年11月9日 · This review demonstrates the progress in the synthesis of radioiodinated compounds over the past decade. The possibilities and limitations of radiopharmaceuticals with different iodine isotopes, as well as the synthesis of low and high molecular weight compounds containing radioiodine, are discussed.