Genetic determinants of micronucleus formation in vivo | Nature
网页2024年2月14日 · To identify factors that can regulate MN formation in vivo, we screened over 6,000 mice across 997 loss-of-function mutant lines, using a highly sensitive detection method that enumerates MN in ...
Micronucleus Assay: The State of Art, and Future Directions
网页2020年2月24日 · During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage.
A high-throughput in vivo micronucleus assay for genome ... - PubMed
网页We describe a sensitive, robust, high-throughput method for quantifying the formation of micronuclei, markers of genome instability, in mouse erythrocytes. Micronuclei are whole chromosomes or chromosome segments that have been separated from the nucleus. Other methods of detection rely on labor-int ….
A high-throughput in vivo micronucleus assay for genome
网页2014年12月31日 · We describe a sensitive, robust, high-throughput method for quantifying the formation of micronuclei, markers of genome instability, in mouse erythrocytes. Micronuclei are whole chromosomes or ...
网页2014年12月31日 · Elevated levels of micronuclei have been associated with tumor predisposition in genetically modified mice11–13, and micronucleus assays have been used to assess the carcinogenic potential of...
In Vivo Micronucleus Assay in Mouse Bone Marrow
网页2019年9月1日 · The mammalian erythrocyte MN assay in bone marrow of rodents is a widely used in vivo assay for genotoxicity testing of chemicals, both as a hazard screening and as a component of exposure-based risk assessments.
A high-throughput in vivo micronucleus assay for genome …
网页We describe a sensitive, robust, high-throughput method for quantifying the formation of micronuclei, markers of genome instability, in mouse erythrocytes. Micronuclei are whole chromosomes or chromosome segments that have been separated from the.
Micronucleus Assay: The State of Art, and Future Directions
网页2020年2月24日 · During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage.
Micronucleus test - Wikipedia
网页A micronucleus test is a test used in toxicological screening for potential genotoxic compounds. The assay is now recognized as one of the most successful and reliable assays for genotoxic carcinogens, i.e., carcinogens that act by causing genetic damage and is recommended by the OECD guideline for the testing of chemicals. [1]
The micronucleus test—most widely used in vivo genotoxicity …
网页2016年10月1日 · The micronucleus was recognized in the end of the 19th century when Howell and Jolly found small inclusions in the blood taken from cats and rats. The small inclusions, called Howell-Jolly body, are also observed in the erythrocytes of peripheral blood from severe anemia patients. These are the first description of the micronucleus itself.