Post-translational modifications of Beclin 1 provide multiple
网页2018年12月13日 · Beclin 1 is a core component of the PI3K complex, important for producing PI (3)P on the phagophore membrane in order to recruit downstream autophagy effectors. Beclin 1 is a multi-domain...
mTOR and Beclin1: Two key autophagy-related molecules and ... - PubMed
网页Mammalian target of rapamycin (mTOR) and Beclin1 are two vital autophagy-related molecules in myocardial I/R injury playing significant roles in different stages.
Targeting autophagy and beyond: Deconvoluting the complexity of Beclin …
网页2023年12月1日 · Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular trafficking events.
mTOR: a pharmacologic target for autophagy regulation - PMC
网页2015年1月2日 · In growing cells, high mTORC1 activity promotes biomolecule synthesis and simultaneously inhibits autophagy. mTORC1 tightly regulates autophagy by suppressing autophagy induction via phosphorylation-dependent inhibition of ULK1/2 and the VPS34 complex and by preventing global expression of lysosomal and autophagy genes through TFEB phosphorylation.
Regulation of Beclin 1-Mediated Autophagy by Oncogenic …
网页2020年12月3日 · Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate autophagy activity in cancer, and some suggest the importance of Beclin 1 tyrosine phosphorylation in this process. Here we ...
Autophagy and mTORC1 regulate the stochastic phase of …
网页2015年5月18日 · The 4F coordinately repress mTORC1, but bifurcate in their regulation of autophagy-related genes, with Klf4 and c-Myc inducing them but Sox2 and Oct4 inhibiting them.
Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
网页2018年10月11日 · Being the master nutrient sensor, the mTORC1 (mammalian target of rapamycin complex 1) signaling is the primary regulator of autophagy initiation in mammalian cells (Kim and Guan, 2015; Rabanal-Ruiz et al., 2017). Under nutrient rich conditions mTORC1 phosphorylates ULK1 and ATG13 in the ULK1 complex effectively suppressing ULK1 activity and ...
mTORC1 signaling and the metabolic control of cell growth
网页2017年4月1日 · mTORC1 signaling stimulates de novo nucleotide synthesis through multiple downstream mechanisms. In response to growth signals, mTORC1 activation leads to S6K1 mediated-phosphorylation of CAD, the rate-limiting enzyme of the de novo pyrimidine synthesis
Structural insights for selective disruption of Beclin 1 binding to …
网页2023年10月24日 · The potential of disruption of the Beclin 1/Bcl-2 interaction for therapeutic use was highlighted by the phenotypes observed in knockin mice bearing an F121A mutation in the BH3 domain of...
Regulation of macroautophagy by mTOR and Beclin 1 complexes
网页2008年2月1日 · Autophagy is regulated by at least two complexes: mTORC1 and Beclin 1/hVps34. Both complexes receive input from intra- and extra-cellular stimuli. mTORC1 integrates nutrients, energy, growth factors, calcium and amino acid signaling. Once activated, mTORC1 inhibits autophagy by acting on the Atg1 kinase complex.