『珍藏版』阴阳相济的中庸之道——AMPK和mTORC1营养感知与 …
网页研究表明，AMPK至少可以通过两条相互平行的途径来抑制mTORC1：其一是通过磷酸化TSC2以直接抑制RHEB和mTORC1的活力；其二是通过直接磷酸化mTORC1复合体上的RAPTOR，造成复合体结构上的变化从而抑制该复合体的活力。
AMPK 通路 | Cell Signaling Technology
网页ampk 是脂代谢和糖代谢的主要调控分子，因此可作为 2 型糖尿病、肥胖症和癌症的潜在治疗靶标。 在许多物种中，AMPK 可以通过与 mTOR 和 sirtuins 相互作用作为衰老的重要调节物。
溶酶体结构和活性调控------AMPK和mTORC1营养感知与细胞生长 …
网页AMPK和mTORC1是感知细胞内营养物质水平、调节代谢平衡，以及调控细胞生长的两大中枢激酶复合体。. 他们分别通过调节一系列下游途径发挥其功能：AMPK感知营养和能量水平较低的状态，并在此条件下被激活，抑制合成代谢途径以减少ATP的消耗，促进分解代谢途径 ...
mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis …
网页The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in response to diverse stimuli such as variations in amino acid content, changes in cellular bioenergetics, oxygen levels, neurotrophic factors and xenobiotics.
Computational modeling of AMPK and mTOR crosstalk in ... - Nature
网页2023年7月17日 · Here, we develop a computational model of synaptic signaling resulting in the activation of two protein kinases critical in metabolic regulation and cell fate, AMP-Activated protein kinase (AMPK)...
How does mTOR sense glucose starvation? AMPK is the usual …
网页2020年4月22日 · Facts. mTORC1 is inhibited by AMPK-dependent and -independent mechanisms upon glucose depletion. mTORC1 recruitment to the lysosomal membrane is critical for mTORC1 activation in response to ...
AMPK: guardian of metabolism and mitochondrial homeostasis
网页2017年10月4日 · AMP-activated protein kinase (AMPK) is a highly conserved sensor of low intracellular ATP levels that is rapidly activated after nearly all mitochondrial stresses,...
Cross-talk between AMPK and mTOR in regulating energy balance
网页Mammalian target of rapamycin (mTOR),is one of the downstream targets of AMPK functions as an intracellular nutrient sensor to control protein synthesis, cell growth, and metabolism. Recent research demonstrated the possible interplay between mTOR and AMPK signaling pathways.
AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
网页2021年9月9日 · In the nutrient signaling, AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) play an important role in balancing cellular energy homeostasis by sensing cellular …
AMPK: guardian of metabolism and mitochondrial homeostasis
网页AMPK and mTOR are both components of ancient conserved pathways that have evolved as a yin-yang-like antagonistic mechanism controlling catabolism and anabolism. A recent study suggests that this regulation of AMPK by axin could play an important role in the activation of AMPK following glucose starvation 56. In this study, the authors propose ...