Lysophosphatidic acid - Wikipedia
网页A lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule. [1][2][3][4] Function. LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPAR1, LPAR2, and LPAR3 (also known as EDG2, EDG4, and EDG7).
Role of lysophosphatidic acid and its receptors in health and …
网页2021年2月1日 · Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the...
Lysophosphatidic Acid - an overview | ScienceDirect Topics
网页Lysophosphatidic acid (LPA) is a simple lipid composed of a glycerol backbone connected to a phosphate head group, and it is commonly ester-linked to an acyl chain. LPA acts as a messenger both inside and outside cells, regulating various cellular responses such as proliferation, apoptosis, migration, and secretion.
Lysophosphatidic Acid Receptors: Biochemical and Clinical …
网页2020年3月15日 · Lysophosphatidic acid (LPA) is essential for brain development and nervous system function, signaling through six different G-protein coupled receptors (LPAR1-6). The role of LPA receptors in the nervous system is one of …
Lysophosphatidic acid, a simple phospholipid with myriad functions
网页2023年6月1日 · Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group, glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA plays an important role as an essential bioactive signaling molecule via its specific six G protein-coupled receptors, …
The role of lysophosphatidic acid in the physiology and ... - PubMed
网页2019年3月1日 · Lysophosphatidic acid (LPA) is the simplest phospholipid found in nature. LPA is mainly biosynthesized in tissues and cells by autotoxin and PA-PLA1α/PA-PLA1β and is degraded by lipid phosphate phosphatases (LPPs). It is an important component of biofilm, an extracellular signal transmitter and intr ….
Emerging roles of lysophospholipids in health and disease
网页2020年11月1日 · Revealing how circulating lysophospholipids are produced, released, transported, and utilized in multi-organ systems is critical to understand their functions. The discovery of enzymes, carriers, transporters, and membrane receptors for these lysophospholipids has shed light on their physiological significance.
Lysophosphatidic acid (LPA) receptors: signaling properties and …
网页Lysophosphatidic acid (LPA), once thought to be an inert metabolite in the biosynthesis of membrane phospholipids, is now well-recognized as an important signaling molecule. Acting through G protein-coupled receptors (GPCRs), LPA alters many different cellular responses, such as proliferation, survival, cytoskeletal changes, calcium influx and ...
Structural insights into ligand recognition by the lysophosphatidic ...
网页2017年8月9日 · Lysophosphatidic acid (LPA) is a bioactive lipid composed of a phosphate group, a glycerol backbone, and a single acyl chain that varies in length and saturation. LPA activates six class A...
Role of lysophosphatidic acid and its receptors in health and …
网页2021年2月1日 · Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which makes this lipid a versatile signaling molecule.
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