Gametocyte - Wikipedia
网页A gametocyte is a eukaryotic germ cell that divides by mitosis into other gametocytes or by meiosis into gametids during gametogenesis. Male gametocytes are called spermatocytes, and female gametocytes are called oocytes.
Revisiting gametocyte biology in malaria parasites - PMC
网页2019年4月9日 · Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology.
Gametogenesis in Plasmodium : Delving Deeper to Connect the Dots
网页2022年6月15日 · Gametogenesis, the process of conversion of gametocytes into viable gametes, takes place inside the mosquito midgut, and is a tightly regulated event with fast and multiple rounds of DNA replication and diverse cellular changes going on …
Targeting Gametocytes of the Malaria Parasite
网页2021年3月16日 · Gametocytes thus provide the essential link for human-to-vector transmission and serve as a promising target to interrupt the parasite life cycle and decrease malaria prevalence. Discussed below are striking features of P. falciparum gametocyte biology that can be exploited to advance novel transmission-blocking strategies.
Plasmodium falciparum Gametocyte Development 1 ( Pfgdv1 ) …
网页2012年10月18日 · Malaria transmission requires the production of male and female gametocytes in the human host followed by fertilization and sporogonic development in the mosquito midgut. Although essential for the spread of malaria through the population, little is known about the initiation of gametocytogenesis in vitro or in vivo.
Expansion microscopy of Plasmodium gametocytes reveals the …
网页2022年1月25日 · In this study, we have implemented expansion microscopy (ExM) techniques to image microtubule structures in Plasmodium gametocytes. ExM consists in physically expanding the cell while keeping its cellular structures intact to allow nanoscale imaging of fluorescently labelled structures with conventional microscopes.
Identification and preliminary characterization of Plasmodium ...
网页2022年6月10日 · This is the first report that identifies proteins secreted/released by activated P. falciparum gametocytes and defines their relative abundance compared to non-activated gametocytes. Our study...
Gametocytes: insights gained during a decade of molecular
网页In vertebrate hosts, malaria parasites produce specialized male and female sexual stages (gametocytes). Soon after being taken up by a mosquito, gametocytes rapidly produce gametes and, once mated, they infect their vector and can be transmitted to new hosts.
Dissecting the role of PfAP2-G in malaria gametocytogenesis
网页2020年3月20日 · We find that PfAP2-G is a transcriptional activator of early gametocyte genes, and identify differences in PfAP2-G occupancy between gametocytes derived via next-cycle and same-cycle conversion.
Repurposing the mitotic machinery to drive cellular elongation …
网页2022年8月27日 · The sexual stage gametocytes of the malaria parasite, Plasmodium falciparum, adopt a falciform (crescent) shape driven by the assembly of a network of microtubules anchored to a cisternal inner...