Cholestane - Wikipedia
网页Cholestane is a saturated C-27 animal biomarker often found in petroleum deposits. It is a diagenetic product of cholesterol, which is an organic molecule made primarily by animals and make up ~30% of animal cell membranes [citation needed].
.Cholestane | C27H48 | CID 637620 - PubChem
网页.Cholestane | C27H48 | CID 637620 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Cholestane - an overview | ScienceDirect Topics
网页Cholesterol is one of the most important chemical compounds in the human body. It is present in all cells primarily as a structural element of lipid bilayers, where it regulates membrane fluidity. Cholesterol is also an essential substrate for the biosynthesis of bile acids, steroid hormones, vitamin D and oxysterols [ 1–3 ].
Cholestane - an overview | ScienceDirect Topics
网页Cholesterol (C 27 H 46 O) is one of the main constituents of plasma membranes. Furthermore, cholesterol is involved in physiological processes of signaling, proliferation, cell death and cell resistance phenotype.
Isolation, structural elucidation, and bioactivity of cholestane ...
网页Phytochemical investigation on the whole plant of Ypsilandra thibetica led to the isolation of five new cholestane derivatives. The structures of 1–5 were elucidated by comprehensive spectroscopic analyses of their data and chemical methods. The absolute configurations of compounds 1–3 were ambiguously assig.
Advancing Diagnosis and Treatment of Niemann-Pick C disease …
网页2021年12月12日 · Niemann-Pick C is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the heterogeneous presentation …
Cholesterol metabolism pathways – are the intermediates more …
网页2021年2月17日 · The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein‐coupled receptors, but perhaps the intermediates in the bile acid biosynthesis pathways are even more interesting and equally important.
The Major Cholesterol Metabolite Cholestane-3β,5α,6β-Triol …
网页2014年8月8日 · Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite of cholesterol, is an endogenous neuroprotectant and protects against neuronal injury both in vitro and in vivo via negative modulation of NMDA receptors. Treatment of cultured neurons with triol protects against glutamate-induced neurotoxicity, and administration of ...
Chemical Synthesis and Biochemical Properties of Cholestane …
网页Cholestane-3β,5α,6β-triol (CT) is a primary metabolite of 5,6-epoxycholesterols (5,6-EC) that is catalyzed by the cholesterol-5,6-epoxide hydrolase (ChEH). CT is a well-known biomarker for Niemann-Pick disease type C (NP-C), a progressive inherited neurodegenerative disease.
Cholestane - NIST Chemistry WebBook
网页Cholestane. Formula: C 27 H 48. Molecular weight: 372.6700. IUPAC Standard InChI: InChI=1S/C27H48/c1-19 (2)9-8-10-20 (3)23-14-15-24-22-13-12-21-11-6-7-17-26 (21,4)25 (22)16-18-27 (23,24)5/h19-25H,6-18H2,1-5H3/t20-,21-,22+,23-,24+,25?,26+,27-/m0/s1. Copy Sheet of paper on top of another sheet.