Cadherin - Wikipedia
网页Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the intracellular cytoplasmic tail associates with numerous adaptors and signaling proteins, collectively referred to as the cadherin adhesome.
Cadherin家族 - 百度百科
网页cadherin家族，即钙离子依赖的细胞粘附素家族 (Ca2+dependent cell adhesion molecule family)，是Takeichi最早发现的一种介导细胞间相互聚集的粘附分子，在有Ca2+存在时，可以抵抗蛋白酶的水解作用，以后又发现了两种作用和特性均与其相类似的粘附分子，它们的氨基 …
你 好，Cadherin ！ - 知乎 - 知乎专栏
网页钙粘蛋白（Cadherin） 是一类I型跨膜蛋白，它们在细胞连接中扮演重要角色，保证了细胞在组织中彼此结合 [1] [2]。. 近年来研究表明其与癌症诊断密切相关，主要是通过 wnt信号通路 影响干细胞分化和肿瘤细胞的扩增，对此展开研究的老师也越来越多 [3] [4 ...
Three Functions of Cadherins in Cell Adhesion - PMC
网页2013年7月7日 · Abstract. Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis. Here, we review the three major functions of cadherins in cell–cell contact formation and stability.
Cadherin Adhesion: Mechanisms and Molecular Interactions
网页We focus on the structure and function of the extracellular domain that controls recognition and adhesive contacts between cadherins on opposing cell surfaces. Classical cadherins, of which E-, P-, N-, and R-cadherin are members, were shown to mediate segregation of different cell populations in early studies.
Role of Cadherins in Cancer—A Review - PMC - National Center …
网页2020年10月15日 · Abstract. Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected with catenins, forming cadherin-catenin complexes, which are crucial for cell-to-cell adherence.
The cadherin superfamily in neuronal connections and …
网页2006年11月29日 · Drosophila melanogaster N-cadherin (DN-cadherin) has been shown to be crucial for the formation of axonal connections with target neurons in both the visual and olfactory systems, and also for...
Structure and functions of classical cadherins - PubMed
网页Cadherins are a family of membrane receptors that mediate calcium-dependent homophilic cell-cell adhesion. Cadherins play a key role in the regulation of organ and tissue development during embryogenesis. In adult organisms, these proteins are responsible for formation of stable cell-cell junctions and maintenance of normal tissue structure.
Cadherin adhesion: mechanisms and molecular interactions
网页Cadherins constitute a superfamily of cell-cell adhesion molecules expressed in many different cell types that are required for proper cellular function and maintenance of tissue architecture. Classical cadherins are the best understood class of cadherins. They are single membrane spanning proteins with a divergent extracellular domain of five ...
Cadherins and cancer: how does cadherin dysfunction promote …
网页2008年11月24日 · In this review, we focus on three potential underlying mechanisms: the capacity of E-cadherin to regulate β-catenin signaling in the canonical Wnt pathway; its potential to inhibit mitogenic ...