Acylhydrazones as Widely Tunable Photoswitches | Journal of the ...
网页2015年11月18日 · Considerable synthetic efforts and complex structure–property relationships render the development and exploitation of new photoswitch families difficult. Here, we focus our attention on acylhydrazones: a novel, yet underexploited class of photochromic molecules based on the imine structural motif.
Acylhydrazones and Their Biological Activity: A Review
网页2022年12月9日 · Introduction. The acylhydrazones, through their structure, have significant malleability both chemically and pharmaceutically. Numerous representatives of this class of organic compounds are intermediates in the synthesis of heterocyclic compounds, including pentatomic ones [1, 2, 3, 4, 5, 6].
Acylhydrazones as Widely Tunable Photoswitches - PubMed
网页2015年12月2日 · Considerable synthetic efforts and complex structure-property relationships render the development and exploitation of new photoswitch families difficult. Here, we focus our attention on acylhydrazones: a novel, yet underexploited class of photochromic molecules based on the imine structural motif.
Isomerization of bioactive acylhydrazones triggered by light
网页2023年6月12日 · Here we analysed two ortho -hydroxylated acylhydrazones discovered in a virtual drug screen for modulators of N -methyl- d -aspartate receptors and other bioactive hydroxylated acylhydrazones...
N-Acylhydrazones as drugs - ScienceDirect
网页2018年9月15日 · Therefore, in this article, we highlight the current status of N-acylhydrazones in drug discovery and development and their role in the next generation of safer and more effective small molecule drug design. The purpose of this article is to provide insight into how medicinal chemists have recognized the significance of …
Acylhydrazones and Their Biological Activity: A Review
网页2022年12月9日 · Due to the structure of acylhydrazones both by the pharmacophore -CO-NH-N= group and by the different substituents present in the molecules of compounds of this class, various pharmacological activities were reported, including antitumor, antimicrobial, antiviral, antiparasitic, anti-inflammatory, i ….
N-Acylhydrazones as drugs - PubMed
网页2018年9月15日 · Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the fail ….
Redox Control over Acyl Hydrazone Photoswitches
网页2017年7月27日 · In this work we developed a method of rapid and tunable Z → E isomerization of C═N bond in acyl hydrazones, using aromatic thiols as nucleophilic catalysts.
New Acylhydrazone Photoswitches with Quantitative Conversion …
网页2019年1月24日 · Hydrazones are recently attracting increasing interest because of their facile synthesis and high addressability, fatigue resistance, and modifiability as molecular switches. However, this new class of switches generally suffers from low conversion from E - to Z -configuration.
N-Acylhydrazones as drugs - ScienceDirect
网页2018年9月15日 · Over the last two decades, N -acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery.