Retroviral Taxonomy, Protein Structures, Sequences, and …
网页Although retroviruses (family Retroviridae) were at one time divided into three subfamilies (Oncovirinae, Spumavirinae, and Lentivirinae), these taxonomic classifications are no longer used. Instead, retroviruses are currently divided into seven genera, and two more groups (the fish retroviruses and the Gypsy group of endogenous viruses of ...
Structure and Classification of Retroviruses | SpringerLink
网页Learn about the common features and diversity of retroviruses, a family of infectious agents that replicate by reverse transcription. Find out the structure and function of their virions, genes, and proteins, and how they are classified and named.
Structural Analysis of Retrovirus Assembly and Maturation
网页2021年12月29日 · In this review we summarize the molecular analysis of the assembly and maturation steps of the life cycle by providing an overview on structural and biochemical studies to understand these processes. We also outline the differences between various retrovirus families with regards to these processes.
Structural Analysis of Retrovirus Assembly and Maturation
网页2021年12月29日 · Retroviruses have a very complex and tightly controlled life cycle which has been studied intensely for decades. After a virus enters the cell, it reverse-transcribes its genome, which is then integrated into the host genome, and subsequently all structural and regulatory proteins are transcribed and translated.
Overview of Retrovirology - PMC - National Center for …
网页Virion Structure. The cartoon illustrates a retrovirus virion. Virion proteins and the RNA genome are illustrated. The NC proteins completely encapsidate the packaged viral RNA. Additional information on the different proteins is found in the text. Some retrovirus particles incorporate additional cellular and host proteins.
Retroviral integrase: Structure, mechanism, and inhibition
网页2021年1月1日 · The retroviral protein Integrase (IN) catalyzes concerted integration of viral DNA into host chromatin to establish a permanent infection in the target cell. We learned a great deal about the mechanism of catalytic integration through structure/function studies over the previous four decades of IN research.
Morphology and ultrastructure of retrovirus particles - PubMed
网页This review focuses on current understanding of the molecular organization of retroviruses derived from the sub-nanometer structures of immature virus particles, helical capsid protein assemblies and soluble envelope protein complexes.
Molecular Biology and Diversification of Human Retroviruses
网页2022年6月1日 · All retroviruses encode a core set of genes in a 5’-gag-pol-env-3’ structure flanked by long-terminal repeats (LTRs) that facilitate replication and integration within the genome. HIV-1, HIV-2, and HTLV-1 also encode a unique set of accessory genes, shown in pink, lime green, and yellow, that help facilitate genomic replication and immune ...
Structural basis for Fullerene geometry in a human endogenous ...
网页2019年12月20日 · Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures...
Mechanisms of Retrovirus Replication | SpringerLink
网页Retroviruses with simple genomes express the polyproteins (i.e., precursor polypeptides) encoded by the following genes: gag for group-specific antigen in the virion core, pol for RNA-dependent DNA polymerase, and env for the viral envelope glycoproig. 2).
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