Ageing and rejuvenation of tissue stem cells and their niches
网页2022年7月20日 · Ageing-associated changes in regenerative tissue regions include defects in maintenance of stem cell quiescence, differentiation ability and bias, clonal expansion and infiltration of immune...
Aged skeletal stem cells generate an inflammatory degenerative niche …
网页2021年8月11日 · Here we show that intrinsic ageing of skeletal stem cells (SSCs) 2 in mice alters signalling in the bone marrow niche and skews the differentiation of bone and blood lineages, leading to...
Niche stiffness regulates stem cell aging | Nature Aging
网页2022年7月15日 · Understanding the molecular mechanisms underlying stem cell aging is essential for improving age-associated stem cell dysfunction. The maintenance of skin epidermis relies on the...
Stem cell aging: mechanisms, regulators and therapeutic …
网页2014年8月6日 · Common pathways contributing to stem cell loss and dysfunction in the aging process. Common aging phenotypes within the stem cell are shown in orange, in the niche in pink, and the strategies by which to target and hopefully reverse these mechanisms in …
Targeting the stem cell niche micro-environment as therapeutic
网页2023年5月19日 · The stem cell niche is a complex and dynamic network surrounding stem cells that plays a crucial role in maintaining stemness. Studies on stem cell niche have suggested that aged niche contributes to the decline in stem cell function. Notably, functional loss of stem cells is highly associated with aging and age-related disorders.
Aging and Rejuvenation of Neural Stem Cells and Their Niches
网页2020年8月6日 · This review discusses mechanisms that regulate neural stem cells (NSCs) during aging, focusing on the effect of metabolism, genetic regulation, and the surrounding niche. We also explore emerging rejuvenating strategies for old NSCs.
A stem cell aging framework, from mechanisms to interventions - Cell …
网页2022年10月18日 · Liu et al. review the landscape of stem cell aging to elucidate aging-related features and mechanisms and interventions for different somatic stem cell types, with a particular focus on epigenetic changes, loss of protein homeostasis, and systemic influencing mechanisms such as chronic inflammation, circadian regulation, and …
Stem Cells and the Niche: A Dynamic Duo - Cell Press
网页Stem cell niches are discrete and dynamic functional domains that influence stem cell behavior to govern tissue homeostasis under diverse physiological (development and aging) and pathological (injury and disease) conditions.
Targeting the stem cell niche micro-environment as therapeutic ...
网页2023年5月19日 · The stem cell niche is a complex and dynamic network surrounding stem cells that plays a crucial role in maintaining stemness. Studies on stem cell niche have suggested that aged niche contributes to the decline in stem cell function. Notably, functional loss of stem cells is highly associated with aging and age-related disorders.
The Mechanism of Stem Cell Aging | Stem Cell Reviews and …
网页2022年1月9日 · Accumulation of DNA damages, imperfect protein homeostasis, altered cellular communication, and exhaustion of stem cells are the main features of aging. In general, when the number of cell divisions reaches the Hayflick limit, cells age and eventually die through apoptosis.
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