Schwann Cell Myelination - PMC - National Center for …
网页New insights into the extrinsic signals and intracellular pathways that drive Schwann cell myelination will be highlighted, including pathways that regulate the actin cytoskeleton during myelin morphogenesis and the transcriptional cascade of myelination.
Schwann cell myelination - PubMed
网页2015年6月8日 — Here, we review our current understanding of the development, molecular organization, and function of myelinating Schwann cells. Recent findings into the extrinsic signals that drive Schwann cell myelination, their cognate receptors, and the downstream intracellular signaling pathways they activate will be described.
Myelinating Schwann cells ensheath multiple axons in the ... - Nature
网页2019年7月5日 — In vertebrates, oligodendrocytes (OLs) and Schwann cells (SCs) are specialized glial cells that generate the myelin sheaths of the central nervous system (CNS) and peripheral nervous system...
Myelination: Current Biology - Cell Press
网页2016年10月24日 — Myelin is formed by Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). Each Schwann cell forms a single myelin sheath around an axon. In contrast, each oligodendrocyte forms multiple sheaths (up to 30 or more) around different axons (Figure 1).
Histology, Schwann Cells - StatPearls - NCBI Bookshelf
网页2023年5月1日 — Schwann cells undergo several phenotypic changes at this time: they activate myelin breakdown, up-regulate the expression of cytokines (including TNF-a) to recruit macrophages to the injury site, up-regulate neurotrophic factors to stimulate axon regeneration and neuron survival, and organize a regeneration pathway along …
Schwann cell development: From neural crest to myelin sheath
网页2020年11月3日 — In vertebrate peripheral nervous systems, neural crest-derived glial cells known as Schwann cells (SCs) generate myelin by encompassing and iteratively wrapping membrane around single axon segments. SC gliogenesis and neurogenesis are intimately linked and governed by a complex molecular environment that …
Schwann Cell Development and Myelination - PubMed
网页2024年9月3日 — In this work, we describe SC development, extrinsic signals from the axon and extracellular matrix (ECM) and the intracellular signaling pathways they activate that regulate SC development, and the morphogenesis and organization of myelinating SCs and the myelin sheath.
Schwann Cell Myelination - cshperspectives.cshlp.org
网页Extrinsic signals from the axon, and the extracellular matrix, drive Schwann cells to adopt a myelinating fate, whereas myelination reorganizes the axon for its role in conduction and is essential for its integrity. Here, we review our current understanding of the development, molecular organization, and function of myelinating Schwann cells.
Schwann Cells: Development and Role in Nerve Repair
网页Schwann cells develop from the neural crest in a well-defined sequence of events. This involves the formation of the Schwann cell precursor and immature Schwann cells, followed by the generation of the myelin and nonmyelin (Remak) cells of mature nerves.
Chapter 5 - Biology of Schwann cells - ScienceDirect
网页2013年1月1日 — Myelination entails expansion and specialization of the Schwann cell plasma membrane over millimeter distances. Many of the myelin-specific proteins have been identified, and transgenic manipulation of myelin genes have provided novel insights into myelin protein function, including maintenance of axonal integrity and survival.