Targeting the biology of aging with mTOR inhibitors - Nature
网页2023年5月4日 — Many of the side effects of rapamycin, which include immunosuppression, hyperlipidemia and hyperglycemia, have raised concerns about the feasibility of using rapamycin to promote healthy...
Multifaceted role of mTOR (mammalian target of rapamycin) …
网页2023年10月2日 — The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain...
Rapamycin and mTOR kinase inhibitors - PMC - National Center …
网页2008年5月15日 — Mammalian target of rapamycin (mTOR) is a protein kinase that controls cell growth, proliferation, and survival. mTOR signaling is often upregulated in cancer and there is great interest in developing drugs that target this enzyme. Rapamycin and its analogs bind to a domain separate from the catalytic site to …
Targeting ageing with rapamycin and its derivatives in humans: a ...
网页Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies.
mTOR as a central hub of nutrient signalling and cell growth
网页2019年1月2日 — The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth regulator connecting...
The mechanistic Target of Rapamycin: The grand conducTOR of …
网页2016年6月6日 — The mechanistic (previously referred to as mammalian) Target Of Rapamycin (mTOR) is a serine/threonine protein kinase that is inhibited by rapamycin, a compound produced by bacteria originally isolated from the soil of Easter Island that inhibits the proliferation of eukaryotic cells (Vezina et al., 1975). The mTOR protein kinase is …
mTOR Signaling in Growth, Metabolism, and Disease - Cell Press
网页The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors.
Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells ...
网页Recent studies demonstrate that BTB integrity is determined by the balance between activities of the two complexes of the serine/threonine kinase mechanistic target of rapamycin (mTOR) in Sertoli cells, whereby mTOR complex one (mTORC1) promotes disassembly of the BTB and mTOR complex two (mTORC2) promotes its integrity (Li and Cheng, 2016; Mok ...
mTOR activity paces human blastocyst stage developmental …
网页2 天之前 — The timing of human blastoid post-implantation development can be paced down by inhibition of mTOR, which elicits a tissue-specific response similar to mouse in vivo diapause.
Mammalian Target of Rapamycin (mTOR): Conducting the …
网页The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2.
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