Ramipril: Uses, Interactions, Mechanism of Action - DrugBank …
网页Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).
Ramipril - StatPearls - NCBI Bookshelf
网页2023年8月17日 · Ramipril is an angiotensin-converting enzyme (ACE) inhibitor and is utilized for multiple indications, including hypertension and prevention of heart failure progression following a myocardial infarction (MI).
Ramiprilat | C21H28N2O5 | CID 5464096 - PubChem
网页An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a drug metabolite, a cardioprotective agent, a matrix metalloproteinase inhibitor and a bradykinin receptor B2 agonist.
Ramiprilat: Uses, Interactions, Mechanism of Action - DrugBank …
网页2018年7月4日 · The therapeutic efficacy of Ramiprilat can be increased when used in combination with Bendroflumethiazide. Benorilate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when …
RAMIPRIL - DailyMed
网页Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl ACE inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.
Ramipril: Dosage, Mechanism/Onset of Action, Half-Life
网页2020年2月10日 · Ramipril is an ACE inhibitor which prevents the formation of angiotensin II from angiotensin I and exhibits pharmacologic effects that are similar to captopril. Ramipril must undergo enzymatic saponification by esterases in the liver to its biologically active metabolite, ramiprilat.
DailyMed - RAMIPRIL tablet
网页2022年11月10日 · Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl angiotensin converting enzyme inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group. Each ramipril tablet intended for oral administration contains 1.25 mg, 2.5 mg, 5 mg and 10 mg of ramipril.
Ramipril Monograph for Professionals - Drugs.com
网页2023年10月26日 · A recommended agent in the management of patients with diabetes mellitus and persistent albuminuria † [off-label] who have modestly elevated (30–300 mg/24 hours) or higher (>300 mg/24 hours) levels of urinary albumin excretion; slows rate of progression of renal disease in such patients.
Clinical pharmacokinetics of ramipril - PubMed
网页Ramipril is a long-acting nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor introduced for clinical use about a decade ago. Ramipril is a prodrug that undergoes de-esterification in the liver to form ramiprilat, its active metabolite. Ramipril rapidly distributes to all tissues, with the l ….
DailyMed - RAMIPRIL capsule
网页2023年11月3日 · Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl ACE inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.
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