My approach to pathology of the pituitary gland - PMC
网页The surgical pathology of this area requires the accurate identification of neoplastic lesions, including pituitary adenoma and carcinoma, craniopharyngioma, neurological neoplasms, germ cell tumours, haematological malignancies and metastases, as well as non‐neoplastic lesions such as cysts, hyperplasias and inflammatory disorders.
Pathology Outlines - Pituitary neuroendocrine tumor (PitNET)
网页2023年10月11日 · Routine assessment of histology includes determination of: Architecture: solid growth, nests, trabeculae or perivascular rosettes. Cytoplasmic features: acidophilia, basophilia, inclusions indicative of fibrous bodies. Nuclear features: mitoses, pleomorphism, giant cells. Other features: inflammatory changes, stroma, hemorrhage, vascular features.
Imaging of pituitary tumors: an update with the 5th WHO …
网页PitNETs/pituitary adenomas are highly concentrated on FDG-PET and may be detected incidentally during PET examinations or in the search for metastases of malignant tumors (Fig. 10). They may be functional or nonfunctioning PitNETs/pituitary adenomas, macroadenomas, or microadenomas.
Acidophil Stem Cell Tumor, Pituitary | SpringerLink
网页2020年5月29日 · Acidophil stem cell adenoma of the pituitary is composed of large pale acidophilic cells with granular cytoplasm and focal clear vacuoles. These tumors exhibit nuclear reactivity for PIT1, variable nuclear staining for estrogen receptor (ER), diffuse cytoplasmic prolactin (PRL), and scattered staining for growth hormone (GH)
Pathology And Pathogenesis Of Pituitary Adenomas And Other …
网页2017年2月15日 · Pituitary adenomas can be classified in various ways, according to size, clinically functional or silent manifestation, hormone or cytokeratin expression profile, defining somatic mutations, and histologic features. The 2004 edition of the WHO classification of endocrine tumours uses markers of cytodifferentiation as …
Neuropathology of Pituitary Adenomas and Sellar Lesions
网页These include lymphocytic hypophysitis and Langerhans cell histiocytosis, a neoplastic disorder of histiocytes. In this review, we aim to briefly describe the main pituitary and sellar lesions, with emphasis on the most common tumors, the PitNETs.
Overview of the 2022 WHO Classification of Pituitary Tumors
网页The new WHO classification provides detailed histological subtyping of a PitNET based on the tumor cell lineage, cell type, and related characteristics. The routine use of immunohistochemistry for pituitary transcription factors (PIT1, TPIT, SF1, GATA3, and ERα) is endorsed in this classification.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS
网页2018年1月19日 · Pituitary adenomas are traditionally defined as benign tumors of the pituitary gland. However, pituitary endocrine neoplasms exhibit a spectrum of clinical behaviors from indolent stable lesions to aggressive, invasive, inoperable, therapy-resistant tumors causing significant morbidity even when they are not metastatic.
Pituitary Adenoma - SpringerLink
网页2020年10月18日 · The pituitary gland is composed of two morphologically and functionally distinct components: the anterior pituitary/adenohypophysis, comprises 80% of gland responsible for pituitary hormone production and the posterior pituitary/neurohypophysis. The production of pituitary hormones is controlled by …
Primary Tumors of the Pituitary Gland: Radiologic-Pathologic ...
网页2021年10月1日 · In summary, primary tumors of the pituitary gland can be subcategorized as common primary tumors of the adenohypophysis (eg, pituitary adenoma), uncommon primary tumors of the Rathke pouch (ie, craniopharyngioma), and rare primary tumors of the neurohypophysis (eg, pituicytoma).